720 North Tustin Avenue
Suite 104
Santa Ana, CA 92705-3606
Phone: (714) 565-1032
Fax: (714) 565-1035

Jeremy E. Kaslow, MD, FACP, FACAAI Physician and Surgeon
Board Certified Internal Medicine

Medical Doctors are licensed and regulated by the Medical Board of California
(800) 633-2322

What is Micro-Dose Bio-Modulation (MDB)?  MDB uses micro-doses of natural products injected into specific tissues to regulate the immune and nervous system.  The resulting modulation (called bioregulation) depends on the choice of the agent and the location (where and how deep) of the injection.  MDB (also known as Biopuncture) developed from a combination of well known injection techniques such as Neural Therapy, Trigger Point Injections, Mesotherapy, Acupuncture Point Injections, and Prolotherapy.  It has distinct features that emphasize clinical response, safety and modulation of the immune and nervous system both in what is injected (biomodulators) and where the injections are given.  Thus, even if other injections have been unsatisfactory or temporary, MDB can be successful both in terms of effect and duration even if the same material was used.

What kind of material is injected?  The micro-doses of natural agents used in bio-puncture are specifically targeted to modulate your innate defense and regulation systems.  For example, scientific investigation has shown that Traumeel inhibits of IL-1b and TNF-alpha secretion.  Cortisone and pharmaceuticals are never used.  The micro-doses used are neither strong enough nor designed to suppress pain or inflammation immediately.  Rather the bio-modulators influence your nervous and immune system.  Just as it is known that one injection of a tetanus vaccine can activate your immune system for about 10 years (memory effect) using only a very dilute dose of tetanus toxin (tetanospasmin).  In the same way, a small dose of a therapeutic bio-modulator can initiate a long-lasting response.  A preservative-free anesthetic (procaine) is used to deliver the bio-modulators and reduce the discomfort of the injection.

Why do bio-modulators need to be injected?  One might ask why you can't ingest or rub in bio-modulators.  The injection adds an extra dimension to the response called "turbo effects," which not only stimulate local and direct effects but also a remote response similar to what is seen when an acupuncture point or nerve center (ganglion) is stimulated or injected.  For example, there is a big difference when Traumeel® is injected into a specific area compared with using Traumeel® tablets.

What should I expect from Micro-Dose Bio-Modulation (MDB)?  Just as you prepare the soil for a garden or wood for painting, the healing process occurs in steps and preparing the tissue is your best chance for long lasting deep results.  Sometimes this can be accomplished in a few sessions, or if you are a hyper-reactor (sensitive to medication, pain, chemically sensitive, unusual responses, etc.), a slower approach is better.  You should expect to receive a few injections at each of a few visits.  Some may hurt and some you may not even feel.  Some injections cause temporary bruising.  Be patient to allow your body to respond.  The dose used is too small to immediately suppress the inflammation but that is not the long term goal.  Regulated and targeted inflammation or detoxification is an important element of healing.  In order to promote a complete healing of the injured or dysfunctional tissues, the natural inflammatory or detoxification process must occur.  As a result, symptom relief may take a while, especially for chronic cases.  But when dealing with acute injuries, the effects of the injections may appear almost immediately.

What will I feel after a Micro-Dose Bio-Modulation (MDB) session?  You should also expect that the response to MDB may include a "reaction phase" in which the pain or detoxification symptoms may be temporarily worse.  This is an indication you are responding.  Because bio-modulators do not contain high concentrations active material, toxic reactions to the bio-puncture are extremely unlikely.  In fact, bio-modulators are guaranteed for quality and are submitted to very strict quality control regulations and systems both in Germany and in the U.S.  These injections have been used in Europe and the U.S. for decades.  Clinical studies on thousands of patients have confirmed the safety of bio-modulators like Traumeel® and Zeel.  ®

One of the most powerful aspects of MDB is its apparent ability to promote detoxification.  Toxins in your body from the environment (air pollution, toxic metals), poor food choices (trans fats), medications (e.g. antibiotics and steroids you've taken), etc. can block your immune defense system and disturb the reflex responses of your nervous system.  This may explain many of your symptoms or why you may not function optimally.  Eliminating toxins is an important strategy, especially when dealing with chronic diseases.  Some injections work specifically on the liver, others on the kidneys, or lymphatic system.

What are some uses for Micro-Dose Bio-Modulation (MDB)?  The most popular use of MDB is minor musculoskeletal problems due to trauma, strain/sprain and/or spasms such as tension headaches, neck pain, shoulder pain, back pain, sciatica, ankle sprain, Achilles tendonitis, sports injuries, tennis elbow, golf elbow, and so on.  Because the immune system is modulated, any condition related to inflammation might be amenable to MDB such as allergies, asthma, eczema, bronchitis, cystitis sinusitis, Crohn's disease, colitis, etc.  Furthermore, the immune system is intertwined with the neurologic system and thus MDB might be useful for cluster headache, neuralgia, migraines, etc.

What does not respond to Micro-Dose Bio-Modulation (MDB)?  MDB cannot heal all your medical problems.  This is not a miracle therapy.  MDB isn't designed to 'take away' or block the pain as with pharmaceuticals.  Pain is an important 'signal' from your body that something is wrong.  Like a red light on your car's dashboard, pain is an indicator for you to correct something.  By the same logic, if your pain is alleviated with MDB there is good reason to conclude the cause of that particular pain has been eliminated.

Micro-Dose Bio-Modulation (MDB) should not be relied upon for cancer, diabetes, a heart attack, AIDS, high blood pressure, Parkinson's, depression or epilepsy.  When serious damage has already occurred, MDB may be too late to reverse.  For example, a viral hepatitis can be treated with MDB in order to support the healing mechanism of the body, but liver cirrhosis is a phase where cells are damaged beyond repair and complete healing is expected.  The same goes for a chronic cough.  MDB can address bronchial inflammation but you would not want to miss lung cancer.  It is important to have a diagnosis before starting any therapy, including MDB.

What about continuing my other therapies with Micro-Dose Bio-Modulation (MDB)?  In some it may be advantageous to combine a conventional approach with MDB.  Many people still believe that one has to stop conventional treatments when choosing natural medicine.  This is not true.  When receiving MDB, continue any medications you were already taking unless instructed otherwise.

Will the Micro-Dose Bio-Modulation (MDB) be the same every visit?  There are three questions to be determined in MDB:

  • What to Bio-modulator should be injected (e.g. -Traumeel®, Lymphomyosot®, Spascupreel®, Engystol®, Zeel®, Discus Compositum®, and/or Coenzyme Compositum®)?
  • Where should the injection be given (reflex zone, pain zones, pain points, trigger points, origin zones and/or origin points)?
  • What tissue should be injected (sub-cutaneous, muscle, soft tissue near or actual tendon, synovium, enthesis, periosteum, and/or ligament)?

Most conditions need to address each of four phases (preparation, immune modulation, treatment, and cellular) and four layers (subcutaneous, muscle, tendon, ligaments).  If you have had problems for several months or even years, you will probably need to work on each different phase and multiple layers.  For this reason it is difficult to predict how many sessions will be necessary.

What risks are associated with Micro-Dose Bio-Modulation (MDB)?  The injections can be painful.  The most common adverse event with MDB in my practice is local transient bruising (a "black-and blue" mark).  You may also have temporary localized numbness from the local anesthetic.  It is theoretically possible to be allergic to the local anesthetic but this may have occurred once and mildly in 20+ years of practice.  The "reaction phase" described above can be intense but it is always transient and is a sign that the bio-modulation is occurring.

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