Leptin Resistance Syndrome: high leptin in the circulation, low leptin
levels in the brain, and leptin resistance in the pancreas causing metabolic
syndrome. Excess cortisol combined with
high circulating leptin promotes abdominal fat deposition and fatigue. Leptin resistance also reduces Growth Hormone
production that is associated with abdominal fat deposition.
low brain and circulating levels of leptin, excess cortisol. Low leptin is associated with depression,
fibromyalgia, bone loss, impaired immunity and liver inflammation.
Rules to manage excess leptin have been proposed.
- Never eat after
dinner. Do not go to bed on a full
- Eat three meals a
day. Do not snack in between meals.
- Do not eat large
meals. Eat slowly to help you feel
- Eat a high
carbohydrate intake. A high sugar meal will
increase leptin secretion 5x over normal. An occasional treat will set back your
fat-burning state for 2-3 days.
MSG. This neurotoxin has been shown to reduce MSH
meals. Starvation response burns protein.
be disguised as dextrose and sucrose
foods which grow beneath ground such
as potatoes, yams, sweet potatoes, beets, carrots, etc. (Onions and garlic are OK)
Cereal grains are the biggest
problem goods (wheat, rice, oats, barley, and rye). Corn has a natural inhibitor of amylase and
thus is OK. Beware that some corn chips have sugar in
syrup, maltodextrin (hidden sugars)
juices, unless you squeeze your own
in terms of amylose. Terrible
in terms of healthfulness.
drinks (coffee/tea): OK
(milk) and fructose (fruit): OK
and yogurt: fat counts
and condiments: OK
and baked corn chips OK, tortilla chips always safe
protein. 6-8 oz. Final cooked weight.
the differences in carbohydrates
moderation in eating includes
eating good food, prepared well, presented pleasingly and eaten with gusto, not
· Carnosine – reduce the
effects of excess adrenaline on the kidneys and leptin resistance.
· Calcium – down
regulates agouti, which amplifies the production of leptin and blocks the
hypothalamic response to leptin. Agouti
and NPY causes food craving and eating. Excess agouti is directly relation to the
accumulation of excess abdominal fat.
Calcium AEP or coral calcium recommended.
· Vitamin D – a powerful
inhibitor of leptin secretion from white adipose tissue and assists in raising
blood calcium levels.
· Serotonin – depresses NPY, which is the key hunger signal in the brain. Thus serotonin indirectly promotes
is inversely related to leptin levels in the brain.
· Melatonin – decreases ghrelin levels, which is produced by the stomach and
transiently stimulates hunger. NPY and Agouti stimulate the production of ghrelin. High fat
diets increase leptin, which depress ghrelin. In turn ghrelin
increases NPY, the brain’s main hunger signal. Grhelin also
stimulates GH release.
· Co Q 10 –enables the
UCP3 system, which enables cells to dispose of excess saturated fat.
· Omega-3 PUFA – reduce the output of TNF-a and
IL-6 from fat cells. In highly
inflammatory states such as with arthritis, can reduce TNF-a by up to 90%. Also proven to reduce insulin resistance.
· CLA – shifts away from
body fat storage, enhances protein synthesis, reduces cancer, atherosclerosis,
prevent diabetes, reduces body fat, improves GH function, reduces leptin
production by up to 42%, and TNF-a and COX-2.
· Acetyl-L-carnitine –
taken at bedtime, ALC stimulates the production of GH
during sleep. Reduces leptin resistance
in the brain, improves cognitive function, mod, depression, stress
response/tolerance, and normalize glucose utilization in the brain.
· Pantethine –
transports fats into metabolic action and breakdown of stored fat. 600-900mg/day lowers LDL and triglycerides,
raises HDL, and reduces blood stickiness.
Reduces fatty liver and visceral fat deposits.
- Leptin Resistance
Resistance: insulin stimulates fat cells to make TNF-a
Promoted/associated with TNF-a and IL-6, which
reduces GI motility
Platelet adhesion increases via leptin
Inflammation binds to GH receptors and turns
them off. IL-6 reduces GH receptor
function in the liver in half.