Estrogen Optimal Use



  • Spread estrogen preferably on the following locations with thin skin: the outer and inner sides of both your arms and shoulders, inner sides of both your thighs, your abdomen (if slender), or your face (may reduce facial hair and wrinkles).

  • Always use the same skin surfaces so the absorption is stable and constant.

  • Spread a thin layer over a large area since only the gel closest to your skin is absorbed.

  • Application to a large surface area enables a longer duration of action since the gel accumulates in the subcutaneous fat and creates a reservoir of estrogen that slowly and progressively gets released into the bloodstream. In contrast, when the gel is applied to a smaller area, the surplus of estrogen will saturate the fat reservoir and release the surplus immediately into the blood stream, which will then be metabolized and disappear.  Half of an arm is not sufficient. Apply over both the inside and outside of both arms or both legs for example.

  • Rub the estrogen cream ten times back and forward to improve deep penetration and absorption.

  • Avoid using creams or lotions over the area where you applied the estrogen.

  • Avoid using oils in your bath water since they block or compete with the estrogen for absorption.

  • If you are not having relief of symptoms or not achieving maximal benefits throughout the day, split the dosage and apply it twice a day (over the same areas).


  • To maintain your level of estrogen, reduce your intake of cereal fiber (whole grain bread, bran flakes, etc.) since they bind estrogens in your intestines and prevent re-absorption back into your body. As a result, less estrogen is available for the tissues you are trying to replenish.  One could also consider reducing foods rich in D-glucarate (apples, grapefruit, broccoli, Brussels sprouts, cabbage, lettuce, and alfalfa) but since it has such a powerful benefit for detoxification and cancer, keep these foods.

  • Follow a Paleolithic food plan, which is similar to the Page Food Plan which emphasizes protein and vegetables.Foods rich in protein and fat increase the production and effects of estrogen and progesterone.

  • Avoid caffeine

  • Avoid processed carbohydrates (sugar, sweets, sodas, high fructose corn syrup, cookies, breads, pasta, cereals, etc.), aspartame, and fruit juices since they stimulate the release of insulin which disrupts sex hormone balance.

  • Avoid milk products since they contain hormone products that further disrupt sex hormone balance.

  • Avoid foods that are likely to have pesticides, herbicides, etc. in them since these bind to estrogen receptors and thus interfere with production and the physiologic response to bio-identical hormones.

  • Excessive stress, both emotionally and physically, is initially associated with over-production of sex hormones and later alters the pituitary signals to the ovaries and adrenals to produce more sex hormones.

BALANCE OTHER HORMONES that affect the secretion of sex hormones and/or their action:

Influence on activity or production of Estrogen and Progesterone





Influence on activity or production of Estrogen



Influence on activity or production of Progesterone


EVIDENCE OF EXCESS ESTROGEN USE:  swollen, painful or tender breasts, nervous, tension, anxiety, irritability, anger outbursts, PMS, weight gain, swollen reddish face, abdominal bloating, hands or feet swelling, heavy menses, painful menses, menstrual migraines.


 September 8, 2008