Oxidative Stress and Antioxidant Testing

 

FRAS - d-ROMs:  this test determines the concentration of hydroperoxides (ROOH) in the blood, which are substances that belong to a broad class of Reactive Oxygen Metabolites (ROMs).  The presence of hydroperoxides (ROOH) in cells indicates oxidative stress on various organic substrates such as carbohydrates, lipids, amino acids, peptides, proteins, hormones, or nucleotides. produced by the attack of free radicals.  Your d-ROMS test value is reported as indicative of low, medium, high, or very high oxidative stress (hydrogen peroxides).  

 

FRAS – PAT:  this test is an automated assay which evaluates the antioxidant potential of blood plasma by measuring its ferric reducing ability. In humans there is a delicate balance between the production and elimination of the so-called free radicals by our antioxidant defense systems.  The alteration of this balance, indicated as oxidative stress, causes cellular lesions which, if severe and continue over time, lead to an acceleration in the aging process and the onset of a large number of diseases.  The PAT (Plasma Antioxidant Test) determines the antioxidant power of plasma.  The test is extremely sensitive to changes.  The PAT test was not designed to provide information on the concentration of an individual antioxidant as this would be of very little clinical value, but to determine the total antioxidant reserve.  The PAT value suggests if there is no, low, medium, or a  significant shortage of anti-oxidant reserve.

 

See: gout, hyperuricemia handout